In a world where the souls of the recently deceased find themselves in a bizarre hospital called Heart's Asylum, players take on the role of a disillusioned soul who must navigate a series of twisted wards, each representing a unique and absurd part of human emotion. From the Ward of Jealousy to the Hall of Regret, players interact with other lost souls and eccentric nurses in their quest to find their misplaced heart. Along the way, they unearth the hilariously tragic stories behind each emotion while making choices that could either restore their heart and bring closure or doom them to wander the asylum forever.