In 'Whose Heart Is It, Anyway?', you play as a heart transplant surgeon with a quirky sense of humor. After a freak accident involving a Halloween party gone wrong, you find yourself in a surreal reality where the hearts of your patients start talking back to you. As you navigate hilarious yet profound conversations with various hearts — each possessing the personality of their former owners — you must solve their quirky dilemmas while making life-and-death decisions. The game's unique mechanic allows each choice to alter the personalities of the patients, leading to multiple outcomes in this darkly comedic exploration of life, death, and identity.