In a dystopian laboratory gone haywire, you play as a witty lab rat named Nibbles who gains self-awareness after a freak experiment. The lab is a chaotic maze of bizarre experiments and eccentric scientists, where you must navigate through a series of absurd tasks and avoid crazy traps set by the mad scientists. Players interact with various characters, including a disgruntled guinea pig and a pompous hamster, forming a ragtag team to create chaos in the lab and ultimately turn the tables on the humans. Your choices impact the storyline, leading to multiple endings where you can either escape, take over the lab, or become a legendary lab rat hero.