You are a cell, constantly working to eliminate misfolded proteins from the nucleus and cytoplasm. In this game, you'll be dealing with the management of misfolded proteins in a unique cellular pathway, coordinating with other compartments of the cell to clear garbage from everywhere. Use genetic, imaging, and biochemical approaches to understand how your cell deals with misfolded proteins, and discover a potential therapy target for age-related diseases like Alzheimer's, Huntington's, and Parkinson's diseases.