Protein Dump is a life simulation game where players take on the role of a cell manager, responsible for controlling the proper disposal of misfolded proteins. Players must make strategic decisions about how to remove toxic proteins while balancing the normal functions of the cell. As players progress, they unlock new clearance mechanisms and must deal with new types of misfolded proteins that threaten the cell's health. The game also includes a research component where players can discover new pathways and therapies to combat age-related diseases.