You are a scientist tasked with creating a new therapy target for age-related diseases like Alzheimer's, Huntington's, and Parkinson's diseases by discovering the new cellular pathway for clearing misfolded proteins from the nucleus. Through genetic, imaging, and biochemical approaches to understand how yeast cells dealt with misfolded proteins, you must find the location where all the misfolded proteins are dumped and create a therapy that can eliminate them. The fate of humanity is in your hands!