Take a thrilling ride inside a cell as you manage protein clearance mechanisms and fight the toxic misfolded proteins that cause Alzheimer's, Parkinson's, and Huntington's diseases. With the discovery of a new pathway for clearing misfolded proteins from the nucleus, the cell is relying on you to manage its garbage dump and kick out the unwanted guests. But be careful - these misfolded proteins are toxic and will try to disrupt your mission at every turn.