Nuclear Dump Squad

As the commander of the Nuclear Dump Squad, your mission is to manage the misfolded protein inclusions in the cytoplasm and nucleus, transport them to the intersection of the vacuole and nucleus, and eliminate them completely. You need to coordinate with your team, assign roles, and make strategic decisions to optimize the protein clearance pathway. But watch out for the aging cells that slow down the process, and the progeria mutants that distort the nuclear envelope. Targeting those diseases requires deep understanding of the cellular mechanism and precise manipulation of the ESCRT II/III and Vps4 proteins.