In 'Mirthquake: Who's Hello Is It Anyway?', players step into the shoes of Bo, an underappreciated stand-up comedian in a quirky alternate reality where humor is a physical force influencing the world around them. When an ancient relic known as the Chuckle Stone goes missing, it unleashes a chaotic mirthquake that scrambles reality itself. Players must navigate bizarre challenges and outrageous characters, solve pun-filled puzzles, and perform hilarious improvised stand-up routines in order to retrieve the Chuckle Stone and restore order. Each decision impacts the comedic situations, leading to multiple endings driven by the laughter generated along the way.