In a high-tech underground laboratory, players take on the role of a sentient lab rat named Rocco, who has been genetically engineered to possess human-like intelligence. After a freak accident during an experiment, Rocco gains the ability to communicate with his fellow lab rats and devises a plan to overthrow the mad scientists conducting cruel tests. Players must navigate a series of whimsical and dangerous challenges—solving puzzles, building makeshift gadgets, and outsmarting both human and mechanical foes. With the help of a motley crew of quirky lab animals, Rocco learns that the only way to escape is to use his wits and creativity. The antics become increasingly dramatic as the lab itself evolves, trying to catch them before they escape to the outside world filled with danger and freedom—a place the rats have only known through the scientists' elaborate video displays.