In a quirky, underground research facility, players assume the role of a sentient lab rat named 'Nibble' who has discovered that the lab's experiments aren't as harmless as thought. Players navigate a series of ethically ambiguous challenges, engaging in witty dialogue with neighboring critters and human scientists, as they aim to gather evidence and orchestrate an uprising against the lab's twisted practices. Throughout the game, players make choices that affect the fate of their fellow lab inhabitants, ranging from organizing a scientific coup to sabotaging their human captors with clever pranks.