Immunological Sleuth is a text-based puzzle game where the player takes on the role of a lab technician trying to solve a medical mystery. Every patient that comes into the lab has a unique T cell receptor sequence, which can contain clues about past and current immune responses. The player must use their knowledge of immunology and data analysis skills to determine which patients have immune traces relevant to specific diseases. Through trial and error and using the linear kernel, players must identify the snippets that correspond to specific diseases to solve the mystery and save lives.