In 'Chrono Conundrum: Who's Ticking?', players assume the role of a time-traveling detective named Wren Quartz, who is tasked with solving the mysterious disappearance of time itself. Wren hops through various pivotal moments in history—from the Renaissance to the Wild West—interacting with eccentric historical figures and piecing together clues. Amidst a backdrop of quirky humor, players must navigate timelines, playing detective while trying to fix the paradoxes that threaten to unravel reality. Each choice impacts not only the story but also Wren's own timeline, leading to multiple endings based on the players' decisions and clever deductions.